The Thermo Fisher Orbitrap Exploris GC sets a new standard for high-resolution gas chromatography-mass spectrometry. Achieving 240,000 mass resolution (FWHM at m/z 200) with sub-ppm mass accuracy, it enables confident identification of unknown compounds in complex matrices without reference standards. Applications include extractables and leachables screening, environmental forensics, metabolomics, and flavor/fragrance analysis. The system features automated tuning, easy-switch between EI and CI modes, and seamless integration with Thermo Fisher Chromeleon CDS and Compound Discoverer software. Deconvolution algorithms automatically separate and identify co-eluting components, dramatically reducing data review time in non-targeted workflows.